Group 1 CD1-restricted T cells take center stage
نویسندگان
چکیده
منابع مشابه
Role of Group 1 CD1-Restricted T Cells in Infectious Disease
The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive vaccine targets that could be recognized in a genetically diverse human population. Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cel...
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The main function of the immune system is to protect the host against microbial pathogens and their deleterious products. Innate defense mechanisms quickly eliminate infectious intruders or keep them in check until highly specific adaptive responses that also give rise to immunological memory are launched. Major histocompatibility complex (MHC)-restricted T cells are key players of adaptive imm...
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متن کاملCD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice
Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)-infected individuals. However, their role and dynamics during infection remain unknown because of the lack of a suitable small animal model. We have generated human group 1 CD1 transgenic (hCD1Tg) mice that express all three human g...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2011
ISSN: 0014-2980
DOI: 10.1002/eji.201141408